Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sole, S. S.
- An Acute Toxicity Study of Tylophora Indica Leaves Extract in Wistar Rats
Abstract Views :227 |
PDF Views:0
Authors
Affiliations
1 Department of Veterinary Pathology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
2 Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, MAFSU, Nagpur – 440006, Maharashtra, IN
3 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, IN
4 Department of Veterinary Public Health, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
5 Department of Veterinary Pharmacology and Toxicology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
6 Hospital Registrar, TVCC Complex, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
1 Department of Veterinary Pathology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
2 Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, MAFSU, Nagpur – 440006, Maharashtra, IN
3 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, IN
4 Department of Veterinary Public Health, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
5 Department of Veterinary Pharmacology and Toxicology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
6 Hospital Registrar, TVCC Complex, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 3 (2018), Pagination: 163-168Abstract
The present investigation was carried out to evaluate the safety of hydroalcoholic extract of Tylophora indica leaves after single dose administration to determine its potential toxicity individually as per Organisation for Economic Co-operation and Development [OECD] 423 guideline. General behaviour, adverse effects and mortality parameters were studied for up to 14 days. Extract was found safe at the oral doses of 2000 mg/kg b. wt. There were no apparent toxicity signs and death observed during experimental trial. Gross necropsy examination revealed no abnormal lesions. In view of the dose of Tylophora indica leaves consumed in traditional medicine, it is observed that there is a wide margin of safety for the therapeutic use.Keywords
Acute Toxicity, OECD Guideline 423, Tylophora Indica, Wistar Rats.
References
- Meyer SA, Kulkarni AP. Hepatotoxicity. Introduction to Biochemical Toxicology. 3rd edn. New York: John Wiley and Sons; 2001. p. 487.
- Wolf PL. Biochemical diagnosis of liver diseases. Indian J Clin Biochem. 1999; 14:59–90. PMid: 23105203 PMCid: PMC3453559. https://doi.org/10.1007/BF02869152.
- Rao GMM, Rao CV, Pushpangadan P, Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. Journal of Ethnopharmacology. 2006; 103(3):484–90. PMid: 16213120. https://doi.org/10.1016/j.jep.2005.08.073.
- Thomas S, Seethe Devi B. Phytochemical and in vitro anthelmintic studies of hydro-alcoholic extract of Costus pictus D. Don. Int J of Pharm Sci. 2013; 5(3):639–41.
- Ayurvedic Pharmacopeia of India. Part I, Vol VI. Appendix6; 2008. p. 247.
- OECD/OCDE OECD Guideline for testing of chemicals. Acute Oral Toxicity - Acute Toxicity Class Method; 2011. p. 423.
- Raina V, Raina S. The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects. Biochemical and Biophysical Research Communications. 1980; 94(4):1074– 7. https://doi.org/10.1016/0006-291X(80)90528-8.
- Mujeeb M, Aeri V, Bagri P, Khan SA. Hepatoprotective activity of the methanolic extract of Tylophora indica (Burm. f.) Merill leaves IJGP. 2009; 3(2):125–7. https://doi.org/10.4103/0973-8258.54901.
- Exposure to Ractopamine Induces Behavioural and Reproductive Alterations in Zebrafish (Danio rerio)
Abstract Views :196 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology and Toxicology, Bombay Veterinary College, Parel, Mumbai – 400012, Maharashtra, IN
2 Maharashtra Animal and Fishery Sciences University, Nagpur – 440006, Maharashtra, IN
1 Department of Pharmacology and Toxicology, Bombay Veterinary College, Parel, Mumbai – 400012, Maharashtra, IN
2 Maharashtra Animal and Fishery Sciences University, Nagpur – 440006, Maharashtra, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 3 (2018), Pagination: 179-190Abstract
The present study was carried out to assess feed additive ractopamine for endocrine disruption in zebrafish. Male zebrafish were exposed to three different doses of ractopamine i.e., 250 ppm, 350 ppm, 450 ppm for 21 days and were observed for behavourial alterations and on mating to unexposed female zebrafish, their embryos were observed for survival and development. It showed that ractopamine was capable of inducing behavioural alterations. There was also effect on male reproduction, which has caused significant reduction in survival and development of embryos over 21 days of exposure. The results demonstrated that ractopamine has the potential to disrupt endocrine system in zebrafish. Therefore, furthermore investigation is necessary in ractopamine production areas for residual content of this drug in water reservoirs for understanding its effects, on the future of animal kind and human kind.Keywords
Endocrine Disruption, Ractopamine, Zebrafish.References
- Caldeira LR, Lima JA, Santos FA, Lana MAG, Ribeiro ACDSR and de Oliveira EC. LC-MS quantification of ractopamine in bovine and swine muscle: Stability of matrix-matched calibration solutions, Accredit Qual. Assur. 2017; 22(2):91–96. https://doi.org/10.1007/s00769-017-1255-y.
- Zhang HY, Zhu WJ. Effects of ractopamine on the in vitro development of cell mouse embryos, AASCIT Journal of Bioscience. 2016; 2(5):42–46.
- Kriewald RD. Effects of Ractopamine HCl on Physical and Reproductive Parameters in the Horse. PhD diss., Texas A & M University; 2010.
- Lawsuit targets FDA approval of controversial animal drugs used in food production, Center for Food Safety. 2014. https://www.centerforfoodsafety.org/press-releases/3591/lawsuit-targets-fda-approval-of-controversial-animal-drugs-used-in-food-production.
- Zhuang Z, Zhao Y, Wu Q, Li M, Liu H, Sun L, Wang D. Adverse effects from clenbuterol and ractopamine on nematode Caenorhabditis elegans and the underlying mechanism, PLoS One 2014; 9(1):e85482. https://doi.
- org/10.1371/journal.pone.0085482. PMid: 24465573, PMCid: PMC3897430.
- Sun L, Wang S, Lin X, Tan H, Fu Z. Early life exposure to ractopamine causes endocrine-disrupting effects in Japanese Medaka (Oryzias latipes), Bull Environ. Contam. Toxicol. 2016; 96(2):150–55. https://doi.org/10.1007/s00128-015-1659-5. PMid: 26395355.
- He J, Gao J, Huang C, Li C Zebrafish models for assessing developmental and reproductive toxicity, Neurotoxicol. Teratol. 2014; 42:35–42. https://doi.org/10.1016/j.ntt.2014.01.006. PMid: 24503215.
- Vogel AM, Weinstein BM. Studying vascular development in the zebrafish, Trends Cardiovasc. Med. 2000; 10(8):352– 360. https://doi.org/10.1016/S1050-1738(01)00068-8.
- National Institute of Health. https://pubchem.ncbi.nlm.nih.gov/compound/ractopamine#section=Top.
- Boaru A, Mahdy CI, Georgescu B. The effect of fipronil on some reproduction parameters of zebrafish (Danio rerio), AACL Bioflux. 2013; 6(2):71–73.
- McElroy JF, Stimmel JJ, O'Donnell JM. Effects of centrally acting beta adrenergic agonists on discrete trial conditioned avoidance behavior in rats, Psychopharmacology. 1989; 97(1):108–14. https://doi.org/10.1007/BF00443423. PMid: 2565587.
- Yaeger MJ, Mullin K, Ensley SM, Ware WA, Slavin RE. Myocardial toxicity in a group of greyhounds administered ractopamine, Vet. Pathol. 2012; 49(3):569–73. https://doi.org/10.1177/0300985811424752. PMid: 21997565.
- Sachett A, Bevilaqua F, Chitolina R, Garbinato C, Gasparetto H, Dal Magro J, Siebel AM. Ractopamine hydrochloride induces behavioral alterations and oxidative status imbalance in zebrafish, J. Toxicol. Environ. Health A. 2018; 81(7):194–201. https://doi.org/10.1080/15287394.20 18.1434848. PMid: 29405861.
- Hurk RV, Lambert JGD. Ovarian steroid glucuronides function as sex pheromones for male zebrafish, Brachydanio rerio, Can. J. Zool. 1983; 61(11):2381–87. https://doi.org/10.1139/z83-317.
- Feild KL, Harp RM, Lambert BD, McGregor KW. The effects of feeding ractopamine hydrochloride to show-type gilts on growth characteristics and reproductive performance, Tex. J. Agric. Nat. Resour. 2016; 21:50–59.
- Aguilera-Soto JI, Ramirez RG, Arechiga CF, MendezLlorente F, Lopez-Carlos MA, Silva-Ramos JM, Duran-Roldan FM. Zilpaterol hydrochloride on performance and sperm quality of lambs fed wet brewers grains, J. Appl. Anim. Res. 2008; 34(1):17–21. https://doi.org/10.1080/09712119.2008.9706933.
- Schiavone AM, Tarantola G, Perona S, Pagliasso P, Badino R, Odore, Lussiana C. Effect of dietary clenbuterol and cimaterol on muscle composition, β‐adrenergic and androgen receptor concentrations in broiler chickens, J. Anim. Physiol. Anim. Nutr. 2004; 88(3‐4). 94–100. https://doi.org/10.1111/j.1439-0396.2003.00464.x. PMid: 15059232.
- Mersmann HJ. Overview of the effects of β-adrenergic receptor agonists on animal growth including mechanisms of action, J. Anim. Sci. Technol. 1998; 76(1):160–72. https:// doi.org/10.2527/1998.761160x. PMid: 9464897.
- Odore R, Badino P, Barbero R,Cuniberti B, Pagliasso S, Girardi C, Re G. Regulation of tissue β-adrenergic, glucocorticoid and androgen receptors induced by repeated exposure to growth promoters in male veal calves, Res. Vet. Sci. 2007; 83(2):227–33. https://doi.org/10.1016/j.rvsc.2006.12.011. PMid:17307208.
- Garofolo MC, Seidler FJ, Cousins MM, Tate CA, Qiao D, Slotkin TA. Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver, Brain Res. Bull. 2003; 59(4):319–29. https://doi.org/10.1016/S0361-9230(02)00925-5.
- Bassett JM, Symonds ME. β2-Agonist ritodrine, unlike natural catecholamines, activates thermogenesis prematurely in fetal sheep, Am. J. Physiol. Regul. Integr. Comp. Physiol. 1998; 275(1):R112–19. https://doi.org/10.1152/ajpregu.1998.275.1.R112. PMid: 9688968.
- Guideline: OECD guidelines 229, fish short term reproductive assay for the testing of chemicals, 2011.